CD62P Rat anti-Mouse, Brilliant Violet 510, Clone: RB40.34, BD Optibuild™
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 740126
The RB40.34 monoclonal antibody specifically binds to mouse P-selectin (CD62P), a 140 kDa protein which is expressed on activated platelets, activated endothelial cells, and megakaryocytes. P-selectin mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells, mediates leukocyte rolling, and is involved in the migration of leukocytes into inflamed tissues. CD24 and CD162 (PSGL-1) are ligands of CD62P. mAb RB40.34 can block mouse P-selectin binding to its ligands in vitro and in vivo.
The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.
|Brilliant Violet 510|
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|IgG1, λ, also known as Lewis IgG1, λ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
|P-selectin; Selp; LECAM3; LYAM3; PADGEM; GMP-140; Grmp|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
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