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CD9 Rat anti-Mouse, Brilliant Violet 786, Clone: KMC8 (also known as KMC 8), BD Optibuild™

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BDB740886 50 μg
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Catalog No. BDB740886 Supplier BD Biosciences Supplier No. 740886
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Description

Rat Monoclonal Antibody

The KMC8 monoclonal antibody specifically binds to CD9 which is also known as Tetraspanin-29 (Tspan29). CD9 is a 24-kDa member of the transmembrane 4 superfamily, also called the tretraspanin family. In the mouse, CD9 is present on bone marrow myeloid cells, stromal cells, and megakaryocyte-committed progenitors; subsets of peripheral T and B lymphocytes; and neutrophils, platelets, dendritic cells, and bone marrow-derived macrophages. CD9 has been found to be associated with integrins and other cell-surface receptors. It appears to play roles in signal transduction and in regulating cellular adhesive properties. CD9 can also reportedly participate in T-cell costimulation and induction of apoptosis. The KMC8 antibody reportedly blocks certain CD9 functions and activates macrophages.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 786-nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60-nm filter).

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD9
Applications Flow Cytometry
Classification Monoclonal
Clone KMC8 (also known as KMC 8)
Concentration 0.2mg/mL
Conjugate Brilliant Violet 786
Description Cd9; Tetraspanin-29; Tspan29
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species Rat
Immunogen (C57BL/6 x DBA/2)F1 mouse bone marrow-derived stromal cell line BMS2
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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