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LPAM-1 Rat anti-Mouse, Brilliant Violet 711, Clone: DATK32, BD Optibuild™

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 740701

Catalog No. BDB740701


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Description

Description

The DATK32 monoclonal antibody specifically binds to an epitope specific for the α 4β 7 integrin heterodimer. α 4β 7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells. It interacts with several ligands, including VCAM-1 (CD106), fibronectin, and MAdCAM-1. DATK32 antibody induces α 4β 7-dependent lymphocyte aggregation, but it inhibits other α

The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405-nm and an acceptor dye with an Em Max at 711-nm. BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20-nm filter). Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors. However, the spillover can be corrected through compensation as with any other dye combination.

Specifications

Specifications

LPAM-1
DATK32
Brilliant Violet 711
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
CDF IgG2a, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Flow Cytometry
0.2mg/mL
Itga4Itgb7; α4β7 Integrin; alpha 4 beta 7 integrin; CD49dβ7
Affinity Purified
AKR/Cum mouse T lymphoma line TK1
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Murine
Documents
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