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MilliporeSigma™ Rat anti-Nup98, Clone: 2H10,

Catalog No. MABE1040MI Shop All MilliporeSigma Products
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MABE1040MI 100 μg
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Catalog No. MABE1040MI Supplier MilliporeSigma™ Supplier No. MABE1040
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Description

Rat Monoclonal Antibody

Specifically detects Nup98 clone: 2H10 in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Western Blotting

The human gene NUP98 (Gene ID 4928; Also known as ADAR2, ADIR2, NUP96, NUP196) encodes the nuclear pore complex protein Nup98-Nup96 (UniProt P52948; also known as GLFG-repeat containing nucleoporin, Nup98-Nup96), which is posttranslationally autocleaved to form Nup98 and Nup96. Cleavage of the Nup98-96 linkage enhances the interaction between Nup98 and Nup96 and promotes localization of the two proteins to the nuclear pore complex (NPC). An alternative splice event generates a mRNA variant (isoform 3; also known as Nup98-specific 1), which expresses only the Nup98 portion of the Nup98-96 mRNA and allows the independent production of Nup98. Unlike Nup96, Nup98 is known to exist in both NPC-bound and non-NPC-associated pool, where it may participate in gene transcription regulations. Nup98 is reported to interact with histone-modifying enzymes CBP/p300 and histone deacetylases (HDACs) through its glycine-leucine-phenylalanine-glycine (GLFG) repeats. NUP98 gene is also involved in chromosomal translocations, resulting in Nup98 translocation fusions identified as potent transcription factors that induce acute myeloid leukemia (AML) with a particularly poor patient prognosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nup98
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone 2H10
Formulation Purified rat monoclonal IgG2cκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P52948
Gene Symbols NUP98; ADAR2
Host Species Rat
Immunogen GST-tagged recombinant protein corresponding to human Nup98 near the N-terminus.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_005378
Target Species Human, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2c κ
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