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MilliporeSigma™ Rat anti-Prohibitin-2/PHB2, Clone: 7F8E3,

Catalog No. MABC953MI Shop All MilliporeSigma Products
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MABC953MI 100 μg
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Description

Rat Monoclonal Antibody

Specifically detects Prohibitin-2/PHB2 clone: 7F8E3 in Human, Monkey, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blotting

Prohibitin-2 (UniProt Q99623; also known as B-cell associated protein, B-cell receptor-associated protein BAP37, BCAP37, D-prohibitin, PHB2, Repressor of estrogen receptor activity) is encoded by the PHB2 (also known as BAP, REA) gene (Gene ID 11331) in human. Prohibitins are assembled into a ring-like PHB complex with 16-20 alternating Phb1 and Phb2 subunits in the inner mitochondrial membrane, where they function as chaperone for respiration chain proteins or as important structural scaffold for optimal mitochondrial morphology and function. Prohibitins are also reported to modulate transcriptions by interacting with various transcription factors, including nuclear receptors. Upregulated expression of prohibitins, septin 9, neurabin 1, and other cytoskeletal and functional proteins is found at the glutathione S-transferase placental-form-positive (GST-P+) hepatocellular carcinoma (HCC) foci during initiation and/or promotion stages of rat hepatocarcinogenesis, implicating an involvement of prohibitins in the neoplastic transformation of rat liver preneoplastic lesions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Prohibitin-2/PHB2
Applications Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 7F8E3
Formulation Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. Q99623
Gene Symbols PHB2; BAP; REA
Host Species Rat
Immunogen KLH-conjugated linear peptide corresponding to human Prohibitin-2/PHB2.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_001138303
Target Species Human, Monkey, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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