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MilliporeSigma™ Rat anti-TEL-AML1 fusion, Clone: 6F2,

Catalog No. MABE1007MI Shop All MilliporeSigma Products
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MABE1007MI 50 μL
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Description

Rat Monoclonal Antibody

Specifically detects TEL-AML1 fusion clone: 6F2 in Human samples, and it is validated for Chromatin Immunoprecipitation, Flow Cytometry, Western Blotting

The chimeric transcription factor TEL-AML1 (ETV6-RUNX1) is the result of the reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration found in childhood B-cell precursor acute lymphoblastic leukaemia (ALL). The runt-homology DNA-binding domain of AML1 retained in the TEL-AML1 mediates the DNA-binding activity of the fusion protein. The fusion protein not only exhibits altered transcription activity, it also affects normal transcription activity by directly competing against wild-type AML1 for promoter binding, sequestering transcriptional cofactors available for the wild-type protein, as well as dimerizing with wild-type protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TEL-AML1 fusion
Applications ChIP Assay, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 6F2
Formulation Purified rat monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P41212; Q01196
Gene Symbols ETV6; TEL; TEL1; RUNX1; AML1; CBFA2
Host Species Rat
Immunogen KLH-conjugated linear peptide corresponding to human TEL-AML1 fusion.
Purification Method Protein G Purified
Quantity 50 μL
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_001978; NP_001116079
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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