MilliporeSigma™ Rat anti-TEL-AML1 fusion, Clone: 6F2,

Rat Monoclonal Antibody

Supplier:  MilliporeSigma™ MABE1007

Catalog No. MABE1007MI

Description

Specifically detects TEL-AML1 fusion clone: 6F2 in Human samples, and it is validated for Chromatin Immunoprecipitation, Flow Cytometry, Western Blotting

The chimeric transcription factor TEL-AML1 (ETV6-RUNX1) is the result of the reciprocal translocation t(12;21)(p13;q22), the most common structural genomic alteration found in childhood B-cell precursor acute lymphoblastic leukaemia (ALL). The runt-homology DNA-binding domain of AML1 retained in the TEL-AML1 mediates the DNA-binding activity of the fusion protein. The fusion protein not only exhibits altered transcription activity, it also affects normal transcription activity by directly competing against wild-type AML1 for promoter binding, sequestering transcriptional cofactors available for the wild-type protein, as well as dimerizing with wild-type protein.

Specifications

• Antigen: TEL-AML1 fusion
• Classification: Monoclonal
• Formulation: Purified rat monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: ETV6; TEL; TEL1; RUNX1; AML1; CBFA2
• Immunogen: KLH-conjugated linear peptide corresponding to human TEL-AML1 fusion.
• Quantity: 50 μL
• Research Discipline: Epigenetics and Nuclear Function
• Gene ID (Entrez): NP_001978; NP_001116079
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
• Isotype: IgG2a κ

• Applications: ChIP Assay, Flow Cytometry, Western Blot
• Clone: 6F2
• Gene Accession No.: P41212; Q01196
• Host Species: Rat
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

For Research Use Only