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Invitrogen™ Rb (Cleaved DRb-p70) Monoclonal Antibody (172C1094)
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Catalog No. 01676588
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Quantity:
100 μg
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Catalog No. Quantity
01-676-588 100 μg
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Catalog No. 01-676-588 Supplier Invitrogen™ Supplier No. MA141186
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Description

Mouse Monoclonal Antibody

Suggested positive control: camptothecin-treated HL-60 (24 hr).

The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Rb (Cleaved DRb-p70)
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 172C1094
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene RB1
Gene Accession No. P06400, P13405
Gene Alias Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; Rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
Gene Symbols RB1
Host Species Mouse
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19645, 5925
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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