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Rb Monoclonal Antibody (XZ133), Invitrogen™

Catalog No. PIMA513653
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500 μL
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Catalog No. Quantity
PIMA513653 500 μL
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Catalog No. PIMA513653 Supplier Thermo Scientific Supplier No. MA513653
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Description

Mouse Monoclonal Antibody

MA5-13653 targets Retinoblastoma in IF and IP applications and shows reactivity with Chicken, Human, and mouse samples. The MA5-13653 immunogen is recombinant human Rb protein corresponding to amino acids 387-928.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Rb
Applications Immunocytochemistry, Immunoprecipitation
Classification Monoclonal
Clone XZ133
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene RB1
Gene Accession No. P06400, P13405, Q90600
Gene Alias Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein
Gene Symbols RB1
Host Species Mouse
Immunogen Recombinant human Rb protein corresponding to amino acids 387-928
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19645, 386582, 5925
Target Species Chicken, Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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