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RB1 Antibody (172C1094), Alexa Fluor™ 750 - (cleaved), Novus Biologicals™
SDP

Catalog No. N10698A70 Shop All R&D Systems Products
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N10698A70 0.1 mL
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Catalog No. N10698A70 Supplier Novus Biologicals Supplier No. NB10056598AF750

Description

Mouse Monoclonal Antibody

RB1 Monoclonal specifically detects RB1 in Human, Mouse samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Knockdown Validated.

Specifications

Antigen RB1
Applications Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen), KnockDown
Classification Monoclonal
Clone 172C1094
Conjugate Alexa Fluor 750
Dilution Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Knockdown Validated
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias OSRC, osteosarcoma, p105-Rb, pp110, pRb, Rb, retinoblastoma 1, retinoblastoma suspectibility protein, retinoblastoma-associated protein
Gene Symbols RB1
Host Species Mouse
Immunogen A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb was used as immunogen.
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 5925
Test Specificity The antibody recognizes cleaved Rb (DRb-p70). The antibody does not recognize full-length Rb. In camptothecin treated HL60, an ∼68 kDa band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Target Species Human, Mouse
Content And Storage Store at 4°C in the dark.
Isotype IgG1
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