RB1 Mouse anti-Human, Clone: OTI13A6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805640

Catalog No. 50-166-7515

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Specifications

• Antigen: RB1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: RB1
• Gene Alias: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5925
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI13A6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P06400
• Gene Symbols: RB1
• Immunogen: Human recombit protein fragment corresponding to amino acids 309-590 of human RB1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1