RB1 (phospho S780) Rabbit anti-Human, Mouse, Rabbit, Polyclonal , Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human RB1.

Supplier:  Abnova Corporation PAB29613

Catalog No. 89-956-786

Description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]

Specifications

• Antigen: RB1 (phospho S780)
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human RB1.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Symbols: RB1
• Immunogen: A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S780 of human RB1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: RB1 (phospho S780) polyclonal antibody detects endogenous level of RB1 only when phosphorylated at serine 780.
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunofluorescence (1:100-1:200) Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) The optimal working dilution should be determined by the end user.
• Gene Alias: OSRC/RB/p105-Rb/pRb/pp110
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5925
• Target Species: Human, Mouse, Rabbit
• Form: Liquid