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Rb2 p130 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986253
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100 μL
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50-198-6253 100 μL
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Catalog No. 50-198-6253 Supplier Bioss Supplier No. BS4984R
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Description

Rabbit Polyclonal Antibody

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 ′Lys20′ trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

Specifications

Antigen Rb2 p130
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene RBL2
Gene Accession No. Q08999
Gene Alias 130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; pRb2; PRIC128; RB transcriptional corepressor like 2; RB2; Rbl2; RBR-2; retinoblastoma-like 2; Retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols RBL2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Rb2 p130.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5934
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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