RBL1 Mouse anti-Human, Clone: OTI4A10, lyophilized, TrueMAB™

Catalog No.	Quantity
50-167-0615	100 μg

Catalog No. 50-167-0615 Supplier OriGene Supplier No. CF811375

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.

Specifications

• Antigen: RBL1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI4A10
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: RBL1
• Gene Accession No.: P28749
• Gene Alias: CP107, PRB1, p107
• Gene Symbols: RBL1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 739-1014 of human RBL1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5933
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a