Invitrogen™ RBM11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531249

Catalog No. PIPA531249

Description

Recommended positive controls: NT2D1, IMR32, U87-MG. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The RBM11 (RNA Binding Motif Protein 11) gene encodes a protein that belongs to a family of RNA-binding proteins involved in the regulation of alternative splicing, a critical process for generating protein diversity. Located on chromosome 21q22.3, RBM11 contains RNA recognition motifs (RRMs) that facilitate its binding to RNA sequences, influencing splice site selection and exon inclusion or exclusion during pre-mRNA processing. RBM11 is expressed in various tissues, with notable expression in the nervous system, suggesting a role in neural development and function. Dysregulation of RBM11 has been associated with various diseases, including cancer, where it can impact the splicing of key regulatory genes involved in cell proliferation and apoptosis. Understanding the specific RNA targets and splicing events regulated by RBM11 can provide insights into its broader biological roles and its potential as a biomarker or therapeutic target in diseases characterized by aberrant splicing.

Specifications

• Antigen: RBM11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rbm11
• Gene Alias: A330018F01; putative RNA-binding protein 11; Rbm11; RNA binding motif protein 11; RNA-binding motif protein 11; Splicing regulator RBM11
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54033
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.56 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P57052
• Gene Symbols: Rbm11
• Immunogen: Recombinant protein encompassing a sequence within the center region of human RBM11. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov