Invitrogen™ RBM11 Polyclonal Antibody

Catalog No.	Quantity
PIPA589087	100 μL

Catalog No. PIPA589087 Supplier Invitrogen™ Supplier No. PA589087

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MFPAQEEADR TVFVGNLEAR VREEILYELF LQAGPLTKVT ICKDREGKPK SFGFVCFKHP ESVSYAIALL NGIRLYGRPI NVQYRFGSSR SSEPANQSFE SCVKINSHNY RNEEMLVGRS SFPMQYFPIN NTSLPQEYFL FQKMQWHVYN PVLQLPYYEM TAPLPNSASV SSSLNHVPDL EAGPSSYKWT HQQPSDSDLY QMTAPLPNSA SVSSSLNHVP DLEAGPSSYK WTHQQPSDSD LYQMNKRKRQ KQTSDSDSST DNNRGNECSQ KFRKSKKKKR Y; Positive Samples: U-87MG, 293T, MCF7, Mouse testis, Rat testis; Cellular Location: Nucleus, Nucleus speckle, nucleoplasm.

The RBM11 (RNA Binding Motif Protein 11) gene encodes a protein that belongs to a family of RNA-binding proteins involved in the regulation of alternative splicing, a critical process for generating protein diversity. Located on chromosome 21q22.3, RBM11 contains RNA recognition motifs (RRMs) that facilitate its binding to RNA sequences, influencing splice site selection and exon inclusion or exclusion during pre-mRNA processing. RBM11 is expressed in various tissues, with notable expression in the nervous system, suggesting a role in neural development and function. Dysregulation of RBM11 has been associated with various diseases, including cancer, where it can impact the splicing of key regulatory genes involved in cell proliferation and apoptosis. Understanding the specific RNA targets and splicing events regulated by RBM11 can provide insights into its broader biological roles and its potential as a biomarker or therapeutic target in diseases characterized by aberrant splicing.

Specifications

• Antigen: RBM11
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.58 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Rbm11
• Gene Accession No.: P57052, Q80YT9
• Gene Alias: A330018F01; putative RNA-binding protein 11; Rbm11; RNA binding motif protein 11; RNA-binding motif protein 11; Splicing regulator RBM11
• Gene Symbols: Rbm11
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human RBM11 (NP_6589833).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 224344, 288321, 54033
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG