Invitrogen™ RBP3 Polyclonal Antibody

Catalog No.	Quantity
PIPA592951	100 μL

Catalog No. PIPA592951 Supplier Invitrogen™ Supplier No. PA592951

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GPTHLFQPSL VLDMAKVLLD NYCFPENLLG MQEAIQQAIK SHEILSISDP QTLASVLTAG VQSSLNDPRL VISYEPSTPE PPPQVPALTS LSEEELLAWL QRGLRHEVLE GNVGYLRVDS VPGQEVLSMM GEFLVAHVWG NLMGTSALVL DLRHCTGGQV SGIPYIISYL HPGNTILHVD TIYNRPSNTT TEIWTLPQVL GERYGADKDV VVLTSSQTRG VAEDIAHILK QMRRAIVVGE RTGGGALDLR KLRIGESDFF FTVPVSRSLG PLGGGSQTWE GSGVLPCVGT PAEQALEKAL AIL; Positive Samples: Mouse lung, Mouse eye, Rat eye; Cellular Location: extracellular matrix, extracellular space, interphotoreceptor matrix.

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.

Specifications

• Antigen: RBP3
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.97 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: RBP3
• Gene Accession No.: P10745, P49194
• Gene Alias: D10S64; D10S65; D10S66; interphotoreceptor retinoid binding protein; interphotoreceptor retinoid-binding protein; interphotoreceptor retinol- binding protein; interstitial retinol binding protein 3; interstitial retinol-binding protein; interstitial retinol-binding protein 3; IRBP; RBP3; Rbp-3; RBPI; retinol binding protein 3; retinol binding protein 3, interstitial; retinol-binding protein 3; RP66
• Gene Symbols: RBP3
• Host Species: Rabbit
• Immunogen: Recombinant protein or (fragment).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19661, 24711, 5949
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov