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Invitrogen™ RC3H1 Polyclonal Antibody
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Catalog No. PIPA555615
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100 μL
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PIPA555615 100 μL
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Catalog No. PIPA555615 Supplier Invitrogen™ Supplier No. PA555615
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AHSQEELEKF RKMNKRLVPR RPLSASLGQL NEVGLPSAAI LPDEGAVDLP SRKPPALPNG IVSTGNTVTQ LIPRGTDPSY DSSLKPG Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 32%.

The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RC3H1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RC3H1
Gene Accession No. Q5TC82
Gene Alias 5730557L09Rik; Gm551; Kiaa2025; mKIAA2025; N28103; probable E3 ubiquitin-protein ligase Roquin; protein Sanroque; RC3H1; RGD1563512; RING CCCH (C3H) domains 1; RING finger and C3H zinc finger protein 1; ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; ring finger and CCCH-type zinc finger domains 1; RING finger protein 198; RNF198; ROQUIN; Roquin-1
Gene Symbols RC3H1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RC3H1. Recombinant protein control fragment (Product #RP-94232).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 149041
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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