Invitrogen™ RC3H1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585598

Catalog No. PIPA585598

Description

Keep as concentrated solution. Predicted reactivity: Mouse (91%). Positive Control: 293T, A431, HeLa, HepG2, 3xFlag-human RC3H1 transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.

Specifications

• Antigen: RC3H1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RC3H1
• Gene Alias: 5730557L09Rik; Gm551; Kiaa2025; mKIAA2025; N28103; probable E3 ubiquitin-protein ligase Roquin; protein Sanroque; RC3H1; RGD1563512; RING CCCH (C3H) domains 1; RING finger and C3H zinc finger protein 1; ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; ring finger and CCCH-type zinc finger domains 1; RING finger protein 198; RNF198; ROQUIN; Roquin-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 149041
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q5TC82
• Gene Symbols: RC3H1
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human RC3H1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG