Invitrogen™ RCAN2 Monoclonal Antibody (1A9)

Catalog No.	Quantity
PIMA524549	100 μg

Catalog No. PIMA524549 Supplier Invitrogen™ Supplier No. MA524549

Description

Mouse Monoclonal Antibody

Peptide Sequence: KAEELHYPLG ERRSDYDREA LLGVQEDVDE YVKLGHEEQQ KRLQAIIKKI DLDSDGFLTE SELSSWIQMS FKHYAMQEAK QQFVEYDKNS DDTVTWDEYN IQMYDRVIDF DENTALDDAE EESFRKLHLK DKKRFEKANQ DSGPGLSLEE FIAFEHPEEV DYMTEFVIQE ALEEHDKNGD GFVSLEEFLG DYRWDPTANE DPEWILVEKD RFVNDYDKDN DGRLDPQELL PWVVPNNQGI AQEEALHLID EMDLNGDKKL SEEEILENPD LFLTSEATDY GRQLHDDYFY HDEL.

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

Specifications

• Antigen: RCAN2
• Applications: ELISA, Western Blot
• Classification: Monoclonal
• Clone: 1A9
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.4
• Gene: Rcan2
• Gene Accession No.: Q14206
• Gene Alias: calcineurin inhibitory protein ZAKI-4; Calcipressin-2; caskin-1-like; CSP2; Dcip2; Down syndrome candidate region 1-like 1; down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene 1-like 1 protein; Down syndrome critical region gene1-like 1; DSCR1L1; DSCR1L1 protein; LOW QUALITY PROTEIN: calcipressin-2; MCIP2; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2; Rcan2; RCN2; regulator of calcineurin 2; si:ch211-124g24.1; thyroid hormone-responsive (skin fibroblasts); thyroid hormone-responsive protein ZAKI-4; translation initiation factor IF-2; ZAKI4; ZAKI-4; zgc:85746
• Gene Symbols: Rcan2
• Host Species: Mouse
• Immunogen: RCN2 (AAH04892.1, 24 a.a. ~ 317 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10231
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ