RCAN2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-7677	100 μL

Catalog No. 50-198-7677 Supplier Bioss Supplier No. BS7028R

Description

Rabbit Polyclonal Antibody

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin′s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

Specifications

• Antigen: RCAN2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Rcan2
• Gene Accession No.: Q14206
• Gene Alias: BOS_21498; Calcineurin inhibitory protein ZAKI-4; Calcipressin-2; CSP2; Dcip2; Down syndrome candidate region 1-like 1; Down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene 1-like 1 protein; Down syndrome critical region gene1-like 1; Dscr1l1; MCIP2; myocyte-enriched calcineurin interactin protein 2; Myocyte-enriched calcineurin-interacting protein 2; RCAN2; RCN2; Regulator of calcineurin 2; si:ch211-124g24.1; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4; ZAKI4; Zaki-4; zgc:85746
• Gene Symbols: Rcan2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human RCAN2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10231
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG