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RCAN2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572458

Catalog No. PIPA572458


Description

Description

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin′s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

RCAN2
Polyclonal
Unconjugated
RCAN2
Csp2; Dscr1l1; MCIP2; ZAKI-4; Down syndrome critical region gene 1-like 1; calcineurin inhibitory protein ZAKI-4; calcipressin-2; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2
Rabbit
Protein A
RUO
10231, 53901
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.25 mg/mL
PBS with 0.09% sodium azide
Q14206, Q9JHG2
RCAN2
KLH conjugated synthetic peptide between 6-37 amino acids from the N-terminal region of human DSCR1L1
400 μL
Primary
Human, Mouse
Antibody
IgG
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