Invitrogen™ REA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579817

Catalog No. PIPA579817

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: PANC Cell, COLO320 Cell, U87Cell, HEPA Cell. IHC: Human Lung Cancer Tissue. ICC/IF: A549 Cell.

PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.

Specifications

• Antigen: REA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHB2
• Gene Alias: AU044498; BAP; Bap37; Bap-37; Bcap27; BCAP37; B-cell associated protein; B-cell receptor associated protein 37; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; hBAP; MGC117268; p22; phb2; phb2 {ECO:0000250; PNAS-141; prohibitin 2; prohibitin-2; Rea; Repressor of estrogen receptor activity; UniProtKB:Q99623}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11331, 114766, 12034
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: O35129, Q5XIH7, Q99623
• Gene Symbols: PHB2
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human REA (111-128aa RPNAQELPSMYQRLGLDY).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG