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R&D Systems™ Recombinant Human DLL4 Fc Chimera Protein
Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands
Supplier: R&D Systems™ 10185D4050
This item is not returnable.
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Description
- Notch signaling is an evolutionarily conserved pathway that controls cell fate and is required in multiple developmental processes including vascular development, hematopoiesis, somatogenesis, myogenesis, and neurogenesis
- Dysregulation in the Notch pathway is associated with various human diseases
- Measured by the ability of the immobilized protein to enhance BMP-2 induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 fort his effect is 0.02-0.12 μg/mL.
Specifications
Q9NR61 | |
54567 | |
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining | |
Human embryonic kidney cell, HEK293-derived human DLL4 protein Human DLL4 (Ser27-Pro524) Accession # Q9NR61IEGRMDPHuman IgG1 (Pro100-Lys330)N-terminus C-terminus |
|
<0.10 EU per 1 μg of the protein by the LAL method | |
Reconstitute at 250 μg/mL in PBS |
Bioactivity | |
81 kDa | |
50 μg | |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. | |
Unconjugated | |
Lyophilized from a 0.2 μm filtered solution in PBS |
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