R&D Systems™ Recombinant Human PVRIG Fc Chimera Protein

Description

Expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells.

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. It is composed of single extracellular IgV domain, one transmembrane domain, and long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is potential docking site for phosphatases. Reconstitute at 500μg/mL in PBS

Storage:

Store the unopened product at −20 to −70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Order Info

Ships at ambient temperature.

Specifications

• Accession Number: Q6DKI7
• For Use With (Application): Bioactivity
• Formulation: Lyophilized from a 0.2 μm filtered solution in MOPS, NaCl and PEG with Trehalose.
• Gene ID (Entrez): 79037
• Molecular Weight (g/mol): 40 kDa
• Quantity: 50 μg
• Source: Human embryonic kidney cell, HEK293-derived human PVRIG protein, (N-terminus) Human PVRIG (Thr41 & Glu43-Leu172) Accession # Q6DKI7 IEGRMD Human IgG1 (Pro100-Lys330) (C-terminus)
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
• Regulatory Status: RUO
• Structural Form: Disulfide-linked homodimer
• Endotoxin Concentration: <0.10 EU per 1 μg of the protein by the LAL method.
• Biological Activity: 0.4 to 2.4μg/mL
• Product Type: Recombinant protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.
• Purity or Quality Grade: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining.

For Research Use Only.