R&D Systems™ Recombinant Human SLURP2 Fc Chimera Protein

Description

The Recombinant Human SLURP2 Fc Chimera Protein is derived from HEK293

• Secreted Ly-6/uPAR domain-containing protein 2 (SLURP2) is expressed primarily in epithelial and immune cells and regulates growth and differentiation of epithelial cells.
• Mature SLURP2 is a secreted protein which is comprised of 75 amino acids. Human SLURP2 shares 65% and 25% aa identity with mouse and rat SLURP2, respectively.
• SLURP2 is demonstrated to lessen the tumorigenic activity of nitrosamines on Het-1A cells, reduce inflammation on human intestinal epithelial cells and Immunocytes such as CEM and U937.
• SLURP2 can interact with alpha 3, alpha 4, alpha 5, alpha 7, beta 2, beta 4, and possibly alpha 6 nicotinic acetylcholine receptors (nAChRs) as well as M1 and M3 muscarinic acetylcholine receptors.
• In addition, SLURP2 controls the proliferation of keratinocytes and epithelial cancer cells via nAChRs on the cell surface.
• It has been suggested SLURP2 may be involved in the pathophysiology of psoriasis through its role in keratinocyte hyper-proliferation and/or T cell differentiation/activation.

Specifications

• Accession Number: P0DP57
• Molecular Weight (g/mol): 35 kDa
• Purification Method: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
• Quantity: 50 μg
• Source:

  Human embryonic kidney cell, HEK293-derived human SLURP2 protein

  MDHuman IgG1 (Pro100-Lys330)IEGRHuman SLURP2 (Ile23-Asp97) Accession # P0DP57N-terminus C-terminus

• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, ≤ -20°C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1 μg of the protein by the LAL method
• Reconstitution: Reconstitute at 500 μg/mL in PBS
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose