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Tocris Bioscience™ RECTAS
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Catalog No. 767950
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76-795-0 50 mg
76-791-0 10 mg
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Catalog No. 76-795-0 Supplier Tocris Bioscience™ Supplier No. 7679/50
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Description

IKBKAP pre-mRNA splicing modulator

RECTAS (rectifier of aberrant splicing) is a pre-mRNA splicing modulator of the IKBKAP (inhibitor of κ light polypeptide gene enhancer in B-cells, kinase complex associated protein) gene. It corrects aberrant IKBKAP splicing in vitro in cellular models of familial dysautonomia and in vivo in transgenic mice. In combination with Phenylbutyric acid (Cat. No. 2682), RECTAS rescues PARK7 aberrant splicing and neuronal cell loss in a midbrain organoid model of familial Parkinson's disease. Orally bioavailable and brain penetrant.

Specifications

Chemical Name or Material 2-Chloro-N-(2-furanylmethyl)-7 H-purin-6-amine
CAS 101862-47-9
Quantity 50 mg
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C10H8ClN5O
Purity 0.98
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