Invitrogen™ RED Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120336

Catalog No. PIPA5120336

Description

Positive test controls include: A-549, HeLa, LO2, Mouse brain, Mouse testis, Rat kidney. The target is usually found in the following locations: Nucleus. Immunogen sequence: MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS.

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

Specifications

• Antigen: RED
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IK
• Gene Alias: arginine/glutamic acid/aspartic acid repeat containing protein; chondrosarcoma-associated protein 2; CSA2; Cytokine IK; Cytokine IK factor; IK; IK cytokine; IK cytokine, down-regulator of HLA II; IK factor; MuRED; prer protein; protein Red; Protein RER; RD element; RED; Rer
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24010, 291659, 3550
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.34 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q13123, Q66HG8, Q9Z1M8
• Gene Symbols: IK
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human IK (NP_006074.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov