Invitrogen™ RED Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532151

Catalog No. PIPA532151

Description

Recommended positive controls: 293T, A431, HepG2. Predicted reactivity: Mouse (96%), Rat (96%), Chicken (87%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.

Specifications

• Antigen: RED
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IK
• Gene Alias: arginine/glutamic acid/aspartic acid repeat containing protein; chondrosarcoma-associated protein 2; CSA2; Cytokine IK; Cytokine IK factor; IK; IK cytokine; IK cytokine, down-regulator of HLA II; IK factor; MuRED; prer protein; protein Red; Protein RER; RD element; RED; Rer
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3550
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.01 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q13123
• Gene Symbols: IK
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 251 and 480 of Human RED.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG