REDD1 Mouse anti-Human, Clone: 1G11, Bethyl Laboratories

Catalog No.	Quantity
50-157-1216	20 μL

Catalog No. 50-157-1216 Supplier Bethyl Laboratories, Inc Supplier No. A500001AT

Description

Mouse Monoclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.

Specifications

• Antigen: REDD1
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 1G11
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: DDIT4
• Gene Accession No.: Q9NX09
• Gene Alias: Protein regulated in development and DNA damage response 1; REDD-1; HIF-1 responsive protein RTP801
• Gene Symbols: DDIT4
• Host Species: Mouse
• Immunogen: Human C-Reaction Protein
• Purification Method: Affinity chromatography
• Quantity: 20 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 54541
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ