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REDD1 Mouse anti-Human, Clone: 1G11, Bethyl Laboratories

Mouse Monoclonal Antibody

Supplier:  Bethyl Laboratories, Inc A500001AT

Encompass_Preferred

Catalog No. 50-157-1216


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Specifications

Specifications

REDD1
Monoclonal
Unconjugated
DDIT4
Protein regulated in development and DNA damage response 1; REDD-1; HIF-1 responsive protein RTP801
Mouse
Affinity chromatography
RUO
54541
4° C
Liquid
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
1G11
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Q9NX09
DDIT4
Human C-Reaction Protein
20 μL
Primary
Human
Antibody
IgG1 κ
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