Invitrogen™ Reelin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104090

Catalog No. PIPA5104090

Description

Antibody detects endogenous levels of total RELN.

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

Specifications

• Antigen: Reelin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RELN
• Gene Alias: ETL7; extracellular matrix serine protease; LIS2; PRO1598; Reelen; reeler; Reeler protein; Reelin; RELN; Rl
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19699, 24718, 5649
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P58751, P78509, Q60841
• Gene Symbols: RELN
• Immunogen: A synthesized peptide derived from human RELN(Accession P78509), corresponding to amino acid residues W294-A344.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov