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Invitrogen™ REG3B Polyclonal Antibody
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Catalog No. PIPA547700
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100 μg
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Catalog No. Quantity
PIPA547700 100 μg
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Catalog No. PIPA547700 Supplier Invitrogen™ Supplier No. PA547700
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Description

Sheep Polyclonal Antibody

In direct ELISAs, approximately 75% cross-reactivity with recombinant rat (rr) Reg3B is observed. In Western blots, approximately 30% cross-reactivity with rrReg3B is observed. In direct ELISAs and Western blots, less than 1% cross-reactivity with rrReg3A, recombinant mouse (rm) Reg3A, and rmReg3G is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

The REG3B gene encodes a protein that is part of the regenerating islet-derived (Reg) family, with significant roles in antimicrobial activity and tissue repair. REG3B is primarily expressed in the pancreas and is implicated in pancreatic regeneration, playing a critical role in conditions such as diabetes and pancreatitis. It exhibits potential therapeutic benefits in tissue injury and inflammatory disorders, including inflammatory bowel disease and acute liver injury. REG3B promotes acinar-to-ductal metaplasia through the activation of the RAS-RAF-MEK-ERK signaling pathway, suggesting its involvement in the early stages of pancreatic ductal adenocarcinoma development. Additionally, REG3B has been identified as an essential regulator of macrophage trafficking in cardiac healing post-myocardial ischemia, aiding in the recruitment and expansion of myeloid cells. Research aims to target REG3B and its receptors to interrupt pathological processes, offering promising avenues for treatment of pancreatic and extrapancreatic diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen REG3B
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Reg3b
Gene Accession No. P35230
Gene Alias HIP; Pancreatitis-associated protein 1; Pap; PAP1; peptide 23; Reg III-beta; Reg2; REG-2; Reg3b; REG-3-beta; regenerating islet-derived 3 beta; regenerating islet-derived protein 3 beta; regenerating islet-derived protein 3-beta; Regenerating islet-derived protein 3-beta 15 kDa form; Regenerating islet-derived protein 3-beta 16.5 kDa form; Regenerating islet-derived protein III-beta; REG-III; RegIII (beta)
Gene Symbols Reg3b
Host Species Sheep
Immunogen E. coli-derived recombinant mouse Reg3B Glu27-Gly175.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18489
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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