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Invitrogen™ REG3B Recombinant Rabbit Monoclonal Antibody (005)
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Catalog No. PIMA536051
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100 μL
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Catalog No. Quantity
PIMA536051 100 μL
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Catalog No. PIMA536051 Supplier Invitrogen™ Supplier No. MA536051
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Mouse REG3B.

The REG3B gene encodes a protein that is part of the regenerating islet-derived (Reg) family, with significant roles in antimicrobial activity and tissue repair. REG3B is primarily expressed in the pancreas and is implicated in pancreatic regeneration, playing a critical role in conditions such as diabetes and pancreatitis. It exhibits potential therapeutic benefits in tissue injury and inflammatory disorders, including inflammatory bowel disease and acute liver injury. REG3B promotes acinar-to-ductal metaplasia through the activation of the RAS-RAF-MEK-ERK signaling pathway, suggesting its involvement in the early stages of pancreatic ductal adenocarcinoma development. Additionally, REG3B has been identified as an essential regulator of macrophage trafficking in cardiac healing post-myocardial ischemia, aiding in the recruitment and expansion of myeloid cells. Research aims to target REG3B and its receptors to interrupt pathological processes, offering promising avenues for treatment of pancreatic and extrapancreatic diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen REG3B
Applications Western Blot
Classification Recombinant Monoclonal
Clone 005
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Reg3b
Gene Accession No. P35230
Gene Alias HIP; Pancreatitis-associated protein 1; Pap; PAP1; peptide 23; Reg III-beta; Reg2; REG-2; Reg3b; REG-3-beta; regenerating islet-derived 3 beta; regenerating islet-derived protein 3 beta; regenerating islet-derived protein 3-beta; Regenerating islet-derived protein 3-beta 15 kDa form; Regenerating islet-derived protein 3-beta 16.5 kDa form; Regenerating islet-derived protein III-beta; REG-III; RegIII (beta)
Gene Symbols Reg3b
Host Species Rabbit
Immunogen Recombinant Mouse REG3B Protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18489
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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