Invitrogen™ REG3G Monoclonal Antibody (C18)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA541665

Catalog No. PIMA541665

Description

REG3G Monoclonal Antibody for Western Blot, IHC (P)

REG3G, also known as regenerating islet-derived 3 gamma, is a gene encoding an antimicrobial peptide crucial for maintaining intestinal homeostasis and regulating host-microbiome interactions. The protein produced by REG3G belongs to the C-type lectin family and is primarily expressed in the gut, where it plays a significant role in defending against bacterial infections. REG3G helps maintain gut barrier function and immune responses, acting in collaboration with interleukin 22 (IL-22), which regulates its expression. This gene is downregulated during chronic ethanol exposure, suggesting an influence on susceptibility to alcoholic liver disease. REG3G is also involved in glucose metabolism, with evidence showing that its administration improves glucose tolerance, potentially through actions mediated by its receptor, Extl3. Furthermore, REG3G has been identified as a nociceptor-enriched hormone, which protects against endotoxic shock by modulating both local and systemic immunity. This diverse functionality underscores the gene's importance in immune modulation, gut physiology, and metabolic processes.

Specifications

• Antigen: REG3G
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P42854, Q6UW15
• Gene Symbols: REG3G
• Immunogen: Recombinant protein Regenerating Islet Derived Protein 3 Gamma. The antigen corresponds to amino acid range 39-175 of the target protein.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Clone: C18
• Conjugate: Unconjugated
• Gene: REG3G
• Gene Alias: AI449515; generating islet-derived, mouse homolog 3 gamma; LPPM429; Pancreatitis-associated protein 1B; pancreatitis-associated protein 3; Pancreatitis-associated protein IB; PAP IB; PAP1B; PAP-1B; Pap3; PAPIB; PAPIII; REG III; Reg III-gamma; REG3G; REG3gamma; REG-3gamma; REG-3-gamma; regenerating family member 3 gamma; regenerating gene III; regenerating islet-derived 3 gamma; regenerating islet-derived protein 3 gamma; regenerating islet-derived protein 3-gamma; Regenerating islet-derived protein 3-gamma 15 kDa form; Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein III-gamma; REG-III; RegIII (gamma); UNQ429; UNQ429/PRO162
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 130120, 24620
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov