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  6. Invitrogen™ REG3G Monoclonal Antibody (D9)

Invitrogen™ REG3G Monoclonal Antibody (D9)
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Catalog No. PIMA541666
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200 μL
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PIMA541666 200 μL
PIMA543611 20 μL
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Catalog No. PIMA541666 Supplier Invitrogen™ Supplier No. MA541666
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Description

Mouse Monoclonal Antibody

REG3G Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

REG3G, also known as regenerating islet-derived 3 gamma, is a gene encoding an antimicrobial peptide crucial for maintaining intestinal homeostasis and regulating host-microbiome interactions. The protein produced by REG3G belongs to the C-type lectin family and is primarily expressed in the gut, where it plays a significant role in defending against bacterial infections. REG3G helps maintain gut barrier function and immune responses, acting in collaboration with interleukin 22 (IL-22), which regulates its expression. This gene is downregulated during chronic ethanol exposure, suggesting an influence on susceptibility to alcoholic liver disease. REG3G is also involved in glucose metabolism, with evidence showing that its administration improves glucose tolerance, potentially through actions mediated by its receptor, Extl3. Furthermore, REG3G has been identified as a nociceptor-enriched hormone, which protects against endotoxic shock by modulating both local and systemic immunity. This diverse functionality underscores the gene's importance in immune modulation, gut physiology, and metabolic processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen REG3G
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone D9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene REG3G
Gene Accession No. P42854, Q6UW15
Gene Alias AI449515; generating islet-derived, mouse homolog 3 gamma; LPPM429; Pancreatitis-associated protein 1B; pancreatitis-associated protein 3; Pancreatitis-associated protein IB; PAP IB; PAP1B; PAP-1B; Pap3; PAPIB; PAPIII; REG III; Reg III-gamma; REG3G; REG3gamma; REG-3gamma; REG-3-gamma; regenerating family member 3 gamma; regenerating gene III; regenerating islet-derived 3 gamma; regenerating islet-derived protein 3 gamma; regenerating islet-derived protein 3-gamma; Regenerating islet-derived protein 3-gamma 15 kDa form; Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein III-gamma; REG-III; RegIII (gamma); UNQ429; UNQ429/PRO162
Gene Symbols REG3G
Host Species Mouse
Immunogen Recombinant protein Regenerating Islet Derived Protein 3 Gamma. The antigen corresponds to amino acid range 39-175 of the target protein.
Purification Method Protein A/G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100240745, 130120, 24620
Target Species Human, Rat, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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