RELA Mouse anti-Human, Clone:6H7, Abnova™

Mouse monoclonal antibody raised against partial recombinant human RELA.

Supplier:  Abnova Corporation MAB17867

Catalog No. 89-334-510

Description

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Specifications

• Antigen: RELA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:100-1:500)
  The optimal working dilution should be determined by the end user.
• Gene: RELA
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 6H7
• Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
• Formulation: In ascitic fluid (0.03% sodium azide)
• Gene Alias: MGC131774, NFKB3, p65
• Immunogen: Recombinant protein corresponding to amino acids 136-224 of human RELA.
• Gene ID (Entrez): 5970
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid