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RELA Mouse anti-Human, Mouse, Clone: 112A1021, Abnova™

Catalog No. 89934850 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-934-850 50 μg
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Catalog No. 89-934-850 Supplier Abnova Corporation Supplier No. MAB12657

Description

Mouse monoclonal antibody raised against human RELA.

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]

Sequence: GLLSGDEDFSSIAD

Specifications

Antigen RELA
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 112A1021
Conjugate Unconjugated
Formulation In PBS (0.05% BSA, 0.05% sodium azide).
Gene Alias MGC131774, NFKB3, p65
Gene Symbols RELA
Host Species Mouse
Immunogen A synthetic peptide corresponding to amino acids 526-539 of human RELA.
Purification Method Protein G purification
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5970
Target Species Human, Mouse
Content And Storage Store at 4°C. For long term storage store at −20°C. Aliquot to avoid repeated freezing and thawing.
Form Purified
Isotype IgG1 κ
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