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Invitrogen™ Relaxin 3 Polyclonal Antibody
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Catalog No. PIPA547448
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100 μg
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PIPA547448 100 μg
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Catalog No. PIPA547448 Supplier Invitrogen™ Supplier No. PA547448
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Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human mature Relaxin-3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Relaxin 3 is part of the Relaxin-like peptide family that plays an important neuropeptide signaling role. Relaxin 3 is a ligand for two structurally related G protein-coupled receptors, human Relaxin receptor 3 and Relaxin receptor 4. The greatest levels of Relaxin 3 expression occur in the brain, specifically in the pons/medulla, with highest levels in the pars ventromedialis of the dorsal tegmental nucleus and with lower levels in the hippocampus and olfactory regions. Significant expression is also observed in the spleen, thymus, lung and ovary. Relaxin 3 inhibits Forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells that express Relaxin receptor 3. Acute and repeated administration of Relaxin 3 causes a decrease in levels of the plasma thyroid stimulating hormone, suggesting that Relaxin 3 may play a role in long-term control of food intake.
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Specifications

Antigen Relaxin 3
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene RLN3
Gene Accession No. Q8WXF3
Gene Alias H3; insl7; insulin-like 7; insulin-like peptide 7; Insulin-like peptide INSL7; M3; PRO20213; Prorelaxin H3; prorelaxin M3; relaxin 3; relaxin-3; Relaxin-3 A chain; Relaxin-3 B chain; RLN3; RXN3; UNQ6188; UNQ6188/PRO20213; ZINS4
Gene Symbols RLN3
Host Species Goat
Immunogen E. coli-derived recombinant human Pro-Relaxin-3 Ala27-Cys142.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117579
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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