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Invitrogen™ Renalase Monoclonal Antibody (1C11E8)
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Catalog No. PIMA531898
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100 μL
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PIMA531898 100 μL
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Catalog No. PIMA531898 Supplier Invitrogen™ Supplier No. MA531898
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Description

Mouse Monoclonal Antibody

MA5-31898 has been tested in indirect ELISA.

Renalase is a flavoprotein enzyme encoded by the RNLS gene, primarily expressed in the kidneys and heart where it plays a critical role in metabolizing catecholamines and catecholamine-like substances. It utilizes nicotinamide adenine dinucleotide (NADH) as a cofactor and operates through a superoxide-dependent mechanism, which is distinct from monoamine oxidase pathways. Renalase is considered a novel renal hormone that influences blood pressure and cardiac function by regulating circulating catecholamines. Its genetic variants have been associated with essential hypertension, highlighting its importance in cardiovascular health. In diabetic nephropathy, renalase exhibits protective effects, as demonstrated in genetically modified mouse models. These models have shown that renalase overexpression can mitigate renal damage, suggesting therapeutic potential. Renalase's expression is highest in the proximal tubules of the kidneys, which are densely innervated by sympathetic nerves, underscoring the connection between renalase and sympathetic nervous system activity. This enzyme's discovery has enriched our understanding of renal hormone regulation and its implications in diseases such as chronic kidney disease (CKD) and end-stage renal disease (ESRD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Renalase
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1C11E8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene Rnls
Gene Accession No. Q5VYX0
Gene Alias 6530404N21Rik; AI452315; alpha-NAD(P)H oxidase/anomerase; AW060440; C10orf59; FLJ11218; HGNC:25641; MAO-C; mMAO-C; monoamine oxidase-C; Renalase; renalase, FAD dependent amine oxidase; renalase, FAD-dependent amine oxidase; RGD1309804; RNLS
Gene Symbols Rnls
Host Species Mouse
Immunogen Purified recombinant fragment of human RNLS (AA: 68-242) expressed in E. coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55328
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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