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Invitrogen™ Renalase Polyclonal Antibody
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Catalog No. PIPA5103006
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PIPA5103006 100 μL
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Catalog No. PIPA5103006 Supplier Invitrogen™ Supplier No. PA5103006
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RNLS.

Renalase is a flavoprotein enzyme encoded by the RNLS gene, primarily expressed in the kidneys and heart where it plays a critical role in metabolizing catecholamines and catecholamine-like substances. It utilizes nicotinamide adenine dinucleotide (NADH) as a cofactor and operates through a superoxide-dependent mechanism, which is distinct from monoamine oxidase pathways. Renalase is considered a novel renal hormone that influences blood pressure and cardiac function by regulating circulating catecholamines. Its genetic variants have been associated with essential hypertension, highlighting its importance in cardiovascular health. In diabetic nephropathy, renalase exhibits protective effects, as demonstrated in genetically modified mouse models. These models have shown that renalase overexpression can mitigate renal damage, suggesting therapeutic potential. Renalase's expression is highest in the proximal tubules of the kidneys, which are densely innervated by sympathetic nerves, underscoring the connection between renalase and sympathetic nervous system activity. This enzyme's discovery has enriched our understanding of renal hormone regulation and its implications in diseases such as chronic kidney disease (CKD) and end-stage renal disease (ESRD).
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Specifications

Antigen Renalase
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Rnls
Gene Accession No. A7RDN6, Q5U2W9, Q5VYX0
Gene Alias 6530404N21Rik; AI452315; alpha-NAD(P)H oxidase/anomerase; AW060440; C10orf59; FLJ11218; HGNC:25641; MAO-C; mMAO-C; monoamine oxidase-C; Renalase; renalase, FAD dependent amine oxidase; renalase, FAD-dependent amine oxidase; RGD1309804; RNLS
Gene Symbols Rnls
Host Species Rabbit
Immunogen A synthesized peptide derived from human RNLS(Accession Q5VYX0), corresponding to amino acid residues A296-I342.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361751, 55328, 67795
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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