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Tocris Bioscience™ RepSox
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Catalog No. 374210
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37-4210 10 mg
37-425-0 50 mg
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Catalog No. 37-4210 Supplier Tocris Bioscience™ Supplier No. 3742/10
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Description

Potent and selective inhibitor of TGF-βRI

RepSox is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and binding respectively). Selective for TGF-β type I receptor over a range of kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces Sox2 by inducing Nanog expression.

RepSox synthesized to Ancillary Material Grade also available.

For more information about how RepSox may be used, see our protocols: Highly Efficient Generation of CiPSCs from MEFs, Generation of β cells from hPSCs, Reprogramming MEFs into Skeletal Muscle Progenitors .

Chemical Identifiers

CAS 446859-33-2
Molecular Formula C17H13N5

Specifications

Quantity 10 mg
Formula Weight 287.32
Purity >99%
Molecular Weight (g/mol) 287.326
Chemical Name or Material RepSox

Safety and Handling

Recommended Storage Store at +4°C
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