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Invitrogen™ REST Monoclonal Antibody (CL0381)
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Catalog No. PIMA524606
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100 μL
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Catalog No. Quantity
PIMA524606 100 μL
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Catalog No. PIMA524606 Supplier Invitrogen™ Supplier No. MA524606
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Description

Mouse Monoclonal Antibody

Immunogen sequence: SPPLPKENLR EEASGDQKLL NTGEGNKEAP LQKVGAEEAD ESLPGLAANI NESTHISSSG QNLNTPEGET LNGKHQTDSI VCEMKMDTDQ NTRENLTGIN STVEEPVSPM LPPSAVEERE AVSKTALA Highest antigen sequence identity to the following orthologs: Mouse - 41%, Rat - 43%. Binds to an epitope located within the peptide sequence ISSSGQNLNT as determined by overlapping synthetic peptides.

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
TRUSTED_SUSTAINABILITY

Specifications

Antigen REST
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL0381
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene REST
Gene Accession No. Q13127
Gene Alias 2610008J04Rik; AA407358; Neural-restrictive silencer factor; neuron restrictive silencer factor; neuron-restrictive silencer factor; NRSF; RE1 silencing transcription factor; RE1-silencing transcription factor; RE1-silencing transcription factor variant E1a/E2/E3/E4c; RE1-silencing transcription factor variant E1a/E2/E3/E5; RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i; RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1a/E2/E4; RE1-silencing transcription factor variant E1a/E2/E5; RE1-silencing transcription factor variant E1a/E2a/E2k; RE1-silencing transcription factor variant E1a/E2d/E4g; RE1-silencing transcription factor variant E1a/E2e/E4h; RE1-silencing transcription factor variant E1a/E2f/E4e; RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j; RE1-silencing transcription factor variant E1b/E2/E3/E5; RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i; RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4; RE1-silencing transcription factor variant E1b/E2a/E2k; RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4; RE1-silencing transcription factor variant E1b/E2e/E4h; RE1-silencing transcription factor variant E1c/E2/E3/E5; RE1-silencing transcription factor variant E1c/E2a/E2k; RE1-silencing transcription factor variant E1c/E2g/E3/E4; repressor binding to the X2 box; Rest; REST4; WT6; X2 box repressor; XBR; zinc finger transcription factor REST protein
Gene Symbols REST
Host Species Mouse
Immunogen Recombinant protein fragment of Human REST (Product #RP-89302)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5978
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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