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  6. Retinal Dehydrogenase 1/ALDH1A1, Mouse anti-Human, Rat, Clone: 16B4.2, Millipore Sigma™

Retinal Dehydrogenase 1/ALDH1A1, Mouse anti-Human, Rat, Clone: 16B4.2, Millipore Sigma™

Catalog No. MABD63425UG Shop All MilliporeSigma Products
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MABD634100 100 μg
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Description

Mouse Monoclonal Antibody

Anti-Retinal Dehydrogenase 1/ALDH1A1, clone 16B4.2, Cat. No. MABD634, is a mouse monoclonal antibody that detects Retinal Dehydrogenase 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Retinal dehydrogenase 1 (UniProt: P00352; also known as EC: 1.2.1.36, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic) is encoded by the ALDH1A (also known as ALDC, ALDH1, PUMB1) gene (Gene ID: 216) in human. Retinal dehydrogenase 1 is a ubiquitously distributed cytosolic enzyme that serves as a detoxification enzyme and also generates retinoic acid. It catalyzes the oxidation of retinal to retinoic acid that is essential for differentiation, development, and survival of dopaminergic neurons. It can also play a role in cellular defense against oxidative stress by oxidizing 4-hydroxynonenal (4-HNE) produced during lipid peroxidation. It is also involved in several other biological processes, such as stem cell maintenance, UV-radiation resistance, melanogenesis, and spermatogenesis, by catalyzing the conversion of specific aldehydes to their corresponding carboxylic acids. Retinal dehydrogenase 1 contains multiple NAD binding sites. (Ref.: Paval, D., et al. (2017). Clin. Psychopharmacol. Neurosci. 5(3); 229-236).
TRUSTED_SUSTAINABILITY

Specifications

Antigen Retinal Dehydrogenase 1/ALDH1A1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 16B4.2
Conjugate Unconjugated
Dilution Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in human liver and rat liver tissue sections.
Formulation Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Alias Retinal dehydrogenase 1;EC: 1.2.1.36;RALDH 1;RalDH1;ALDH-E1;ALHDII;Aldehyde dehydrogenase family 1 member A1;Aldehyde dehydrogenase;cytosolic
Gene Symbols ALDH1A;ALDC;ALDH1;PUMB1
Host Species Mouse
Immunogen KLH-conjugated linear peptide corresponding to 18 amino acids from the C-terminal region of human retinal dehydrogenase 1.
Purification Method Protein G purified
Quantity 25 μg
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_000680
Test Specificity Clone 16B4.2 detects Retinal dehydrogenase 1/ALDH1A1. it targets an epitope with in 18 ammo acids from the C-terminal region.
Target Species Human, Rat
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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