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Invitrogen™ RFC1 Polyclonal Antibody
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Catalog No. PIPA595728
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100 μL
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PIPA595728 100 μL
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Catalog No. PIPA595728 Supplier Invitrogen™ Supplier No. PA595728
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Description

Rabbit Polyclonal Antibody

Positive Samples: MCF7; Cellular Location: Nucleus Immunogen sequence: PKGAENCLEG LIFVITGVLE SIERDEAKSL IERYGGKVTG NVSKKTNYLV MGRDSGQSKS DKAAALGTKI IDEDGLLNLI RTMPGKKSKY EIAVETEMKK ESKLERTPQK NVQGKRKISP SKKESESKKS RPTSKRDSLA KTIKKETDVF WKSLDFKEQV AEETSGDSKA RNLADDSSEN KVENLLWVDK YKPTSLKTII GQQGDQSCAN KLLRWLRNWQ KSSSEDKKHA AKFGKFSGKD DGSSFKAALL SGPPGVGKTT TASLVCQELG YSYVELNASD TRSKSSLKAI VAESLNNTSI K.

Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide binding consensus sequences. Four of the five RFC genes (RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC2, the third-largest subunit of the RFC complex, exhibits ATP binding which makes it important for both DNA replication and checkpoint function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RFC1
Applications ELISA, Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1.74 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene RFC1
Gene Accession No. P35251, P35601
Gene Alias 140kDa; A1; A1 140 kDa subunit; A1-P145; Activator 1 140 kDa subunit; activator 1 large subunit; Activator 1 subunit 1; Alp145; Differentiation-specific element-binding protein; DNA-binding protein PO-GA; Ibf-1; ISRE-binding protein; MHC binding factor, beta; MHCBFB; PO-GA; RECC1; replication factor C (activator 1) 1; replication factor C (activator 1) 1, 145kDa; replication factor C 1; replication factor C 140 kDa subunit; Replication factor C large subunit; replication factor C subunit 1; Replication factor C subunit 1-like protein; replication factor C, 140 kDa; replication factor C1; RFC; RF-C 140 kDa subunit; Rfc1; RFC140
Gene Symbols RFC1
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19687, 5981, 89809
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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