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Invitrogen™ RFC1 Polyclonal Antibody
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Catalog No. PIPA5102446
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100 μL
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PIPA5102446 100 μL
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Catalog No. PIPA5102446 Supplier Invitrogen™ Supplier No. PA5102446
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RFC1.

Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide binding consensus sequences. Four of the five RFC genes (RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC2, the third-largest subunit of the RFC complex, exhibits ATP binding which makes it important for both DNA replication and checkpoint function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RFC1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene RFC1
Gene Accession No. P35251, P35601
Gene Alias 140kDa; A1; A1 140 kDa subunit; A1-P145; Activator 1 140 kDa subunit; activator 1 large subunit; Activator 1 subunit 1; Alp145; Differentiation-specific element-binding protein; DNA-binding protein PO-GA; Ibf-1; ISRE-binding protein; MHC binding factor, beta; MHCBFB; PO-GA; RECC1; replication factor C (activator 1) 1; replication factor C (activator 1) 1, 145kDa; replication factor C 1; replication factor C 140 kDa subunit; Replication factor C large subunit; replication factor C subunit 1; Replication factor C subunit 1-like protein; replication factor C, 140 kDa; replication factor C1; RFC; RF-C 140 kDa subunit; Rfc1; RFC140
Gene Symbols RFC1
Host Species Rabbit
Immunogen A synthesized peptide derived from human RFC1(Accession P35251), corresponding to amino acid residues S259-E309.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19687, 5981, 89809
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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