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RFC1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981250
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50-198-1250 100 μL
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Catalog No. 50-198-1250 Supplier Bioss Supplier No. BS11304R
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Description

Rabbit Polyclonal Antibody

Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide binding consensus sequences. Four of the five RFC genes (RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC2, the third-largest subunit of the RFC complex, exhibits ATP binding which makes it important for both DNA replication and checkpoint function.

Specifications

Antigen RFC1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene RFC1
Gene Accession No. P35251
Gene Alias 140kDa; A1; A1 140 kDa subunit; A1-P145; Activator 1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; Alp145; Differentiation-specific element-binding protein; DNA-binding protein PO-GA; germ line transcription factor 1-like; Ibf-1; ISRE-binding protein; LOC100352565; MHC binding factor, beta; MHCBFB; PO-GA; Recc1; replication factor C (activator 1) 1; replication factor C (activator 1) 1, 145kDa; replication factor C 1; Replication factor C 140 kDa subunit; Replication factor C large subunit; Replication factor C subunit 1; replication factor C, 140 kDa; replication factor C1; RFC; RF-C 140 kDa subunit; RFC1; RFC140
Gene Symbols RFC1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human RFC1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5981
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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