Invitrogen™ RFTN1 Polyclonal Antibody

Catalog No.	Quantity
PIPA587893	100 μL

Catalog No. PIPA587893 Supplier Invitrogen™ Supplier No. PA587893

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGCGLNKLEK RDEKRPGNIY STLKRPQVET KIDVSYEYRF LEFTTLSAAE LPGSSAVRLA SLRDLPAQLL ELYQQGFSLA ALHPFVQPTH EREKTPLEHI FRAILIKKTD RSQKTDLHNE GYILELDCCS SLDHPTDQKL IPEFIKKIQE AASQGLKFVG VIPQYHSSVN SAGSSAPVST ANSTEDARDA KNARGDHASL ENEKPGTGDV CSAPAGRNQS PEPSSGPRGE VPLAKQPSSP SGEGDGGELS PQGVSKTLDG; Positive Samples: A-549, Mouse liver; Cellular Location: Cell membrane, Lipid-anchor.

Raftlin, also known as RFTN1 (raftlin, lipid raft linker 1), cell migration-inducing gene 2 protein, PIB10, PIG9 or MIG2, is a 578 amino acid cell membrane protein and lipid anchor that is essential for raft cell assembly and maintenance. A member of the raftlin family, Raftlin modulates B-cell antigen receptor-mediated signaling, TCR signals, and is involved in T cell-mediated immune responses. The gene encoding Raftlin maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Specifications

• Antigen: RFTN1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.83 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Rftn1
• Gene Accession No.: Q14699, Q6A0D4
• Gene Alias: 2310015n21rik; AI853526; Cell migration-inducing gene 2 protein; KIAA0084; MIG2; PIB10; PIG9; proliferation-inducing protein 10; proliferation-inducing protein 9; Raftlin; raftlin lipid raft linker 1; raftlin, lipid raft linker 1; raft-linking protein; Rftn1; RGD1310777; RGD1563347
• Gene Symbols: Rftn1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RFTN1 (NP_0559651).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23180, 501095, 76438
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov