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Invitrogen™ RGMA Monoclonal Antibody (275407)
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Catalog No. PIMA523977
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100 μg
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Catalog No. Quantity
PIMA523977 100 μg
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Catalog No. PIMA523977 Supplier Invitrogen™ Supplier No. MA523977
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Description

Rat Monoclonal Antibody

In direct ELISAs and Western blots, 100% cross-reactivity with recombinant human RGM-A and recombinant chicken RGM is observed. In Western blots, approximately 25% cross-reactivity with recombinant mouse RGM-C is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGMA
Applications Western Blot
Classification Monoclonal
Clone 275407
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene RGMA
Gene Accession No. Q6PCX7, Q8JG54, Q96B86
Gene Alias BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
Gene Symbols RGMA
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse RGM-A Cys48-Gly421.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 244058, 395214, 56963
Target Species Human, Mouse, Chicken
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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