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Invitrogen™ RGMA Monoclonal Antibody (OTI4G8)
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Catalog No. PIMA527491
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100 μL
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PIMA527491 100 μL
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Catalog No. PIMA527491 Supplier Invitrogen™ Supplier No. MA527491
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Description

Mouse Monoclonal Antibody

RGMA Monoclonal Antibody for IHC (P)

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGMA
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone OTI4G8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RGMA
Gene Accession No. Q96B86
Gene Alias BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
Gene Symbols RGMA
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 169-424 of RGMA produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56963
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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