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RGMA Mouse anti-Human, Clone: OTI1C5, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF811571

Encompass_Preferred

Catalog No. 50-167-0725


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Specifications

Specifications

RGMA
Monoclonal
Unconjugated
RGMA
RGM
Mouse
Affinity Chromatography
RUO
56963
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI1C5
PBS with 8% trehalose and no preservative; pH 7.3
Q96B86
RGMA
Human recombit protein fragment corresponding to amino acids 169-424 of human RGMA produced in E.coli.
100 μg
Primary
Human
Antibody
IgG2a
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