RGMA Mouse anti-Human, Clone: OTI4G8, lyophilized, TrueMAB™

Catalog No.	Quantity
50-167-0720	100 μg

Catalog No. 50-167-0720 Supplier OriGene Supplier No. CF811560

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Specifications

• Antigen: RGMA
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: OTI4G8
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: RGMA
• Gene Accession No.: Q96B86
• Gene Alias: RGM
• Gene Symbols: RGMA
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 169-424 of human RGMA produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 56963
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a